Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability.

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial cells and secreted into wound and airway surface fluid. Here we show that LL-37 induces angiogenesis mediated by formyl peptide receptor-like 1 expressed on en...

Pseudomonas aeruginosa Invasion by Permeability, and Prevents Epithelial Cell Stiffness, Decreases Transepithelial Cathelicidin LL-37 Increases Lung Epithelial

Involvement of the antimicrobial peptide LL-37 in human atherosclerosis.

OBJECTIVE Antimicrobial peptides are effector molecules of the innate immune system. To understand the function of vascular innate immunity in atherosclerosis, we investigated the role of LL-37, a cathelicidin antimicrobial peptide, in the disease process. METHODS AND RESULTS Using real-time polymerase chain reaction, we found a 6-fold increase in human cationic antimicrobial protein 18/LL-37...

Evaluating the Antiviral Activities of Human Cathelicidin LL-37 Peptide Against Rotavirus in Vitro

Background Rotavirus is the most prevalent cause of severe gastroenteritis, hospitalizations, and deaths among infants and young children, globally. No specific antiviral drug is available against rotavirus infection.  Objective The current study aimed to assess the antiviral effect of human cathelicidin antimicrobial peptide LL-37 on rotavirus infection in vitro.  Methods  This study was con...

Effect of antimicrobial cathelicidin peptides on the endothelial cell apoptosis

Endothelial cells function as a barrier between the intravascular compartment and extravascular tissues. At the site of inflammation, endothelial cells are impaired through the apoptosis, and vascular integrity is disrupted. Thus, apoptosis of endothelial cells triggers the microcirculatory disorder and organ dysfunction, and its attenuation is considered to be one of the therapeutic strategies...